BiographyDr. Nikki Gentile is an Assistant Professor in the UW Departments of Family Medicine and Laboratory Medicine and Pathology and is the Primary Care Medical Director of the UW Post-COVID Rehabilitation and Recovery Clinic. After earning her PhD in Comparative Pathology from the University of California, Davis, she completed her MD training at Tulane University School of Medicine followed by Family Medicine residency and chief resident year at UW. She currently practices hospital medicine and outpatient primary care at UW, and multidisciplinary post-COVID care at the Harborview Post-COVID Rehabilitation and Recovery Clinic.
Dr. Gentile’s graduate research in the Department of Pathology and Laboratory Medicine at UC Davis involved designing and executing bench and clinical validation testing on, and assessing performance and clinical effectiveness of, novel point-of-care (POC) tests, including glucometers and multiplex nucleic acid tests (e.g., linear-after-the-exponential polymerase chain reaction [LATE-PCR], loop-mediated isothermal amplification [LAMP]). These studies funded by RC-1 Challenge and U54 grants were done in collaboration with industry partners, other academic institutions, and the NIH. She also has background in developing novel sample prep for extracting DNA from complex media (i.e., blood), which has been patented by prior industry partners for use in POC nucleic acid tests.
In residency, Dr. Gentile was a co-PI overseeing research studies involving implementation of physical activity vital sign (PAVS) in the primary care setting under the “Exercise Is Medicine” initiative at UW. These population health studies analyzed the association between physical inactivity and chronic disease burden, mental health, and healthcare utilization in primary care patients, as well as investigating provider practices and needs surrounding exercise promotion.
Her recent/current research aims at advancing translational medicine on the front lines of the COVID-19 pandemic, including examining (1) diagnostic/laboratory testing modalities and access, (2) impact of COVID on mental health and healthcare utilization, (3) health disparities related to COVID, (4) disease severity, associated symptoms, and comorbidities in long COVID, as well as performing clinical trials testing integrative medicine approaches to treat long COVID, including acupuncture and mindfulness. She is also passionate about translational medicine and research spanning direct clinical care and laboratory medicine. She was a key member of the CDC funded RELIEF study team, and currently serves as site co-investigator for the CDC-funded INSPIRE Registry, a large multi-center, longitudinal cohort examining predictors of long-term consequences of COVID-19. As a PI, she is currently building a research program aimed at studying long COVID-related pain and potential treatments. In her first year as research faculty, her team received a UW Royalty Research Fund (RRF) award for a mixed methods study exploring autoantibody abnormalities and impact of pain on quality of life and function in patients with long COVID-related pain seen in the Post-COVID Rehabilitation and Recovery Clinic.
Aside from grant-funded research efforts, Dr. Gentile is passionate about residency education and mentoring future physician scientists. She is the developer and faculty lead for the Research Track and longitudinal Scholarship & Research curriculum in the UW Family Medicine Residency.
PublicationsThompson M and Gentile N Advocating for patients through laboratory tests: what do GPs’ use of blood tests for suspected cancer tell us?. BJGP. 2023;73(727): 52-53. 2023
Gottlieb M, Spatz ES, Yu H, Wisk L, Elmore JG, Gentile NL, et al. Long COVID Clinical Phenotypes up to 6 Months After Infection Identified by Latent Class Analysis of Self-Reported Symptoms.. Open Forum Infectious Diseases. Volume 10, Issue 7, July 2023
Spatz ES, Gottlieb M, Wisk LE, Anderson J, Chang AM, Gentile NL, et al. Three-Month Symptom Profiles Among Symptomatic Adults With Positive and Negative Severe Acute Respiratory Syndrome Coronavirus 2 Tests: A Prospective Cohort Study From the INSPIRE Group. Clin Infect Dis . May 3;76(9):1559-1566. 2023
Copley M, Kozminski B, Gentile N, Geyer R, Friedly J. Postacute Sequelae of SARS-CoV-2: Musculoskeletal Conditions and Pain. Phys Med Rehabil Clin N Am. Apr 14 2023
Cai X, Ebell MH, Geyer RE, Thompson M, Gentile NL, Lutz B. The impact of a rapid home test on telehealth decision-making for influenza: a clinical vignette study.. BMC Prim Care. . 2022 Apr 13;23(1):75. 2022
Lin C. Ball T, Gentile NL, et al. Associations Between Physical Activity Vital Sign in Patients and Healthcare Utilization, 2018-2020.. J Phys Act Health. 2022;20(1):28-34 2022
Wisk LE, Gottlieb MA, Spatz ES, Yu H, Wang RC, Slovis BH, Saydah S, Plumb ID, O’Laughlin KN, Montoy JCC, McDonald SA , Lin Z, Lin JMS, Koo K, Idris AH, Huebinger RM,Hill MJ, Gentile NL, Chang AM, Anderson J, Hota B, Venkatesh AK, Weinstein RA, Elmore JG, Ni G Association of Initial SARS-CoV-2 Test Positivity With Patient-Reported Well-being 3 Months After a Symptomatic Illness. JAMA Network Open. Dec 2022
Lin CY, Gentile NL, Bale L, Rice M, Lee ES, Ray LS, Ciol MA Implementation of a Physical Activity Vital Sign in Primary Care: Associations Between Physical Activity, Demographic Characteristics, and Chronic Disease Burden. Prev Chronic Dis. Jun 2022
O’Laughlin KN, Thompson M, Hota B, Gottlieb M, Plumb ID, Chang AM, Wisk LE, Hall AJ, Wang RC, Spatz ES, Stephens KA, Huebinger RM, McDonald SA, Venkatesh A, Gentile N, Slovis BH, Hill M, Saydah S, Idris AH, Rodriguez R, Krumholz HM, Elmore JG., Weinstein RA, & Nichol G. Study protocol for the Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): A longitudinal study of the medium and long-term sequelae of SARS-CoV-2 infection. PLOS One. Mar 2022
Gentile NL, Dillier AM, Williams GV, Ackers J, Reis AH Jr., Rice LM, Wangh L, Czajka J, Kost GJ. Verification of monoplex and multiplex linear-after-the-exponential PCR gene-specific sepsis assays using clinical isolates. . Journal of Applied Microbiology . 114:586-594 2013